Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB
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چکیده
منابع مشابه
Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB.
Adult neural stem cells (NSCs) are defined by their inherent capacity to self-renew and give rise to neurons, astrocytes, and oligodendrocytes. In vivo, however, hippocampal NSCs do not generate oligodendrocytes for reasons that have remained enigmatic. Here, we report that deletion of Drosha in adult dentate gyrus NSCs activates oligodendrogenesis and reduces neurogenesis at the expense of gli...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2016
ISSN: 1934-5909
DOI: 10.1016/j.stem.2016.07.003